IndraLab

Statements

CACNA1C increases the amount of calcium(2+). 3 / 3
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"In addition, we observe pathway hits in calcium signaling, specifically at RhoA, AKAP6, and calcium channels CACNA1C and CACNA2D3, all of which modulate calcium levels, which, in turn, through calcinuerin signaling, regulate the transcriptional activity of another associated gene in the calcium signaling pathway, NF-AT."
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"In this paradigm of oxidative cell death, we found that both Cacna1c gene silencing and pharmacological inhibition of LTCC using nimodipine significantly diminished the glutamate induced rise in mitochondrial calcium levels."
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"Our findings are further strengthened by accumulating evidence that RYR3 modulates Abeta plaque deposition and that CACNA1C increases intracellular calcium levels in the presence of Abeta."
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