IndraLab

Statements

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"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."
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"In a previous study, isoliquiritigenin among TFGU potently inhibited the activation of NLRP3 inflammasome, and its inhibitory effect was stronger than that of parthenolide, a known inhibitor of the NLRP3 inflammasome."
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"XREF_BIBR, XREF_BIBR Isoliquiritigenin has been shown to inhibit ASC oligomerization and activation of the NLRP3 inflammasome in macrophages as well as inflammation in adipose tissue."
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"Isoliquiritigenin from the roots and rhizomes of Glycyrrhiza plants also inhibits NLRP3 inflammasome activation and subsequent IL-1beta production as well XREF_BIBR."
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"Administration of isoliquiritigenin (a flavonoid from the roots of Glycyrrhiza glabra) after ICH reduced early brain injury and neurological deficits, suppressing ROS and/or NF-kappaB-mediated NLRP3 inflammasome activation by promoting the Nrf2 antioxidant pathway [XREF_BIBR]."
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"Other proposed inhibitors include MCC950 which more specifically targets NLRP3 [ xref ], isoliquiritigenin which also inhibits NLRP3 [ xref ], and CRID3, the cytokine release inhibitor drug which disrupts IL-1β secretion [ xref ]."
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