IndraLab

Statements

BAP1 inhibits RB1. 2 / 2
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"A recent study demonstrated that, in contrast to wild-type animals, CDKN2A loss is not required for tumorigenesis in BAP1 +/- mice, They further demonstrated that BAP1 mediates Rb1 expression loss via epigenetic down-regulation independent of CDKN2A status [XREF_BIBR]."
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reach
"MM cells from Bap1 +/- mice show biallelic inactivation of Bap1 and Cdkn2a independent downregulation of Rb."
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