IndraLab

Statements

USP37 activates GLI1. 3 / 3
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"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
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"Furthermore, knockdown of USP37 expression significantly decreased the stability of Gli-1 protein both in MCF-7 and MDA-MB-231 cells (Fig. 7d and e)."
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"Knockdown of USP37 significantly decreased hedgehog (Hh) pathway components Smo and Gli-1."
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