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USP19 deubiquitinates BAG6. 7 / 7
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"Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer."
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"Overexpression of USP19 significantly decreased ubiquitination of BAG6, but increased BAG6 protein level when compared with the control group (Figure 4A)."
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"Next, to investigate whether the ability of USP19 to deubiquitinate BAG6 was dependent on its protease activity, we transfected WT‐USP19 or its mutants into cells."
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"Overexpression of WT‐USP19 reduced BAG6 ubiquitination, but transfection with the C607S‐USP19 plasmid had no effect on BAG6 ubiquitination (Figure 4B)."
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"28 , 29 Overexpression of USP19 significantly inhibited the WT and K29‐linked polyubiquitination of BAG6, but did not affect the other ubiquitination linkages (K6, K11, K27, K33, K48 or K63) in BAG6 (Figure 4C)."
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"This was in agreement with USP19 knockdown increasing K29‐linked ubiquitination of BAG6 (Figure 4D)."
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"In this study, we found, for the first time, that USP19 reduced ubiquitination and degradation of BAG6 to induce BC cell apoptosis and ER stress."
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