IndraLab

Statements

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"The parent gene USP1 also enhanced the viability and mobility of GC cells."
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"Then, real-time cellular analysis (RTCA) showed that USP1 knockdown inhibited GC metastasis both in vitro and in vivo."
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"Mechanically, we demonstrated that USP1 promoted GC metastasis via upregulating ID2 expression and further confirmed that USP1 stabilized ID2 expression through deubiquitinating ID2 in GC."
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"In conclusion, our study showed that USP1 promoted GC metastasis via stabilizing ID2 expression, which provides a potential biomarker and therapy target for GC."
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"USP1 is upregulated in GC and promotes GC cell growth and metastasis."
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"Transwell assays presented that USP1 overexpression markedly promoted migration and invasion of GC cells (Fig. 6k, m, Supplementary Fig. S6f, h), while its knockdown exerts opposite effects (Fig. 6l, n, Supplementary Fig. S6g, i)."
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"USP1 Promotes GC Metastasis via Stabilizing ID2."
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"Taken together, these results indicated that USP1 promotes the growth and metastasis of GC cells."
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