IndraLab

Statements

COPS5 activates localization. 8 / 8
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"Inhibitors of CSN5 and HDAC2, identified as the posttranslational modification regulators of PD-L1, can reduce PD-L1 stability and nuclear localization, respectively, providing an effective approach for combinational therapy with the help of immune checkpoint therapy (41, 44, 47)."
36893266
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"Jab1 and CSN5 induces the cytoplasmic localization and degradation of RUNX3."
19350572
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"Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein."
16882664
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"In this study, we found that activating ESD by FPD5 significantly inhibited the interaction between JAB1 and p53, which would reduce the effect of nuclear exportation of p53 by JAB1, which increased the nuclear localization of p53 and provided a good condition for p53 to regulate other genes’ expression in the nucleus."
35627173
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"We demonstrate here that ESD increases the nuclear localization of p53 by JAB1, and it is vitally important to find a new factor to regulate p53 and inhibit tumor growth.Here, we found that a novel factor esterase D (ESD) reduced the interaction between JAB1 and p53 to suppress cancer cell growth."
35627173
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"Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2."
16624822
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"Jun activation domain binding protein 1 (Jab and CSN5) induces the cytoplasmic localization and degradation of RUNX3 [XREF_BIBR]."
21268057
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"JAB1 induces p53 cytoplasmic localization and its subsequent degradation, which helps to maintain low levels of p53 under normal conditions XREF_BIBR, XREF_BIBR, XREF_BIBR."
24870804