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NS1643 activates KCNH6. 4 / 4
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"The concentration-response curve for NS1643 activation of ERG2 channels is summarized in Fig. 1 D."
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"NS1643 was able to increase ERG2 peak tail current amplitude at potentials from approximately −90 mV to 0 mV."
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"In summary, NS1643 activated ERG2 channels by a diminutive but highly significant left-ward shift of activation concomitant with a faster time-constant of activation, a slower time-constant of inactiv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, the different profile of ERG1 and ERG2 channel activation by NS1643 may be useful in structure-function studies of the two channel subtypes.To further characterize the pharmacology of ERG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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