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Arg-Val inhibits MAVS. 3 / 3

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"Since MAVS acts upstream of both IRF3 and NF-κB signaling, we next examined the functional significance of RV-induced MAVS degradation."

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"Remarkably, mutagenesis of the SPLTSS motif to six alanines completely abolished RV-induced MAVS degradation (Figure 4G)."

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"Of note, replication of a simian RV, which is unable to degrade murine MAVS, is significantly enhanced in Mavs-/- mice."

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IndraLab

Statements

Arg-Val inhibits MAVS. 3 / 3

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