IndraLab

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Arg-Val inhibits MAVS. 8 / 8
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"Of note, replication of a simian RV, which is unable to degrade murine MAVS, is significantly enhanced in Mavs-/- mice."
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"Since MAVS acts upstream of both IRF3 and NF-κB signaling, we next examined the functional significance of RV-induced MAVS degradation."
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"Remarkably, mutagenesis of the SPLTSS motif to six alanines completely abolished RV-induced MAVS degradation (Figure 4G)."
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"Similarly, only the two reassortant RVs derived from the cross of simian RRV and murine EW RVs, both of which encoded a murine RV VP3 (B7/2 and D6/2), were able to degrade murine MAVS in NIH3T3 cells as compared to WT RRV(Figure 3-figure supplement 1B, lower panel)Figure 2 continuedActive RV replication induces proteasomal degradation of MAVS."
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"Here, we found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction, is degraded by the RV RNA methyl-and guanylyl-transferase (VP3) in a host-range-restricted manner."
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"Here, we found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction 3, is degraded by the RV RNA methyl- and guanylyl-transferase (VP3) in a host-range-restricted manner."
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"Since MAVS acts upstream of both IRF3 and NF-kB signaling, we next examined the functional significance of RV-induced MAVS degradation."
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"In the present study, we report the unexpected discovery that the RV RNA capping enzyme VP3, an important RV structural protein, recently shown to also possess phosphodiesterase (PDE) activity , also mediates MAVS degradation in an RV strain-specific manner."
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