IndraLab

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USP15 binds NFE2L1. 5 / 5
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"Consistently, 3 x Flag-Nrf1 was coprecipitated with V5-USP15, indicating that USP15 physically interacts with Nrf1 in cells.We next examined whether USP15 stabilizes Nrf1 through its deubiquitination."
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"USP15 physically interacts with Nrf1, and it markedly stabilizes Nrf1 by removing its ubiquitin moieties."
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"Nevertheless, the coexpression of 3 x Flag-Nrf1 caused the nuclear translocation of V5-USP15, implying a physical interaction between USP15 and Nrf1 in cells (top panels)."
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"To address this hypothesis, we first examined an association between USP15 and Nrf1 using immunoprecipitation."
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biogrid
No evidence text available
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