IndraLab

Statements


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"Flag-tagged Dub3 expression resulted in the same effect and also 53BP1 foci induced by treating cells with etoposide was completely inhibited by expression of Dub3 WT ( Figure S1D and data not shown)."

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"USP44, USP17L2/DUB3, USP11, ZUFSP and POH1 loss promotes the excessive spreading of Ub at DSBs and concomitant excessive accumulation of 53BP1 [57–65]."

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"Importantly, Dub3 overexpression abrogates focus formation of 53BP1 and breast cancer type 1 susceptibility protein (BRCA1) in response to genotoxic stress [98]."