IndraLab

Statements

CTNNB1 phosphorylates CTNNB1 on S37. 4 / 4
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"Phosphorylation of beta-catenin by glycogen synthase kinase (GSK)-3beta at Ser33 and Ser37 and Thr47 targets beta-catenin for ubiquitination and proteosomal degradation XREF_BIBR."
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"Previous studies have verified that the beta-catenin destruction complex mediates sequential phosphorylation of beta-catenin at S45, T41, S37 and S33 for subsequent ubiquitination and proteasomal degradation and thereby maintains low baseline cytosolic levels of the protein in cancer cells XREF_BIBR, XREF_BIBR."
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"Levels of stabilized form of β-catenin were visualized using the ABC antibody ( Fig. 1 C) that recognize β-catenin that is not phosphorylated at residues S37 and T41, two of the sites that are phospho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This phosphorylation renders beta-catenin a primed substrate for glycogen-synthase kinase 3 (GSK3), which, in turn, continue to phosphorylate beta-catenin at T41, S37, and S33."
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