IndraLab

Statements

USP14 activates CGAS. 4 / 4
| 1 3
eidos
"USP14 promotes cGAS signaling by removing K48-linked ubiquitin chain of cGAS ."
28744851
reach
"The authors ascribed these phenotypes to TRIM14 's role in promoting cGAS stabilization and provide evidence that loss of TRIM14 allows for cGAS degradation via the E3 ligase USP14, which targets cGAS to p62 dependent selective autophagy."
32404352
reach
"USP14 promotes cGAS signaling by removing K48‐linked ubiquitin chain of cGAS."
28744851
reach
"During DNA viral infection, USP14 modulates cGAS stability, indicating a function in immunity."
28746868