IndraLab

Statements

USP14 activates CGAS. 4 / 4
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"During a DNA virus infection, the E3 ubiquitin-substrate ligase TRIM14, an IFN-stimulated gene (ISG), induces the cleavage of cGAS by the deubiquitinase ubiquitin-specific peptidase 14 (USP14)."
38675916
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"USP14 promotes cGAS signaling by removing K48‐linked ubiquitin chain of cGAS."
28744851
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"The authors ascribed these phenotypes to TRIM14 's role in promoting cGAS stabilization and provide evidence that loss of TRIM14 allows for cGAS degradation via the E3 ligase USP14, which targets cGAS to p62 dependent selective autophagy."
32404352
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"During DNA viral infection, USP14 modulates cGAS stability, indicating a function in immunity."
28746868