IndraLab

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MSH4 activates EIF3F. 2 / 5
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"Conversely, eIF3f significantly increased the sensitivity of cells treated with 2Gy IR and hMSH4 substantially promoted this effect."

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"Furthermore, the interplay between hMSH4 and eIF3f inhibits IR induced AKT activation, and hMSH4 promotes eIF3f mediated bypass of S phase arrest, and ultimately enhancing an early G2/M arrest in response to IR treatment."