IndraLab

Statements

KCNH2 activates terbinafine. 6 / 6
| 6
reach
"Terbinafine targets ERG1, which is the upstream gene for ERG11, the target for posaconazole."
27415801
reach
"Under both conditions of iron‐sufficiency and iron‐depletion, ERG1 overexpression increased terbinafine resistance, as it resulted in higher IC80 values (Figure 2C, S2B)."
35837730
reach
"Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene."
12963042
reach
"In general, Erg1 downregulation by iron chelation causes an increase in terbinafine susceptibility, although the degree of susceptibility varies among the strains."
35837730
reach
"Overexpression of ERG1 increases resistance to terbinafine."
35837730
reach
"Highest squalene levels (over 1000mug squalene per 10 (9) cells) were induced by specific point mutations in ERG1 gene that reduced activity of squalene epoxidase and caused hypersensitivity to terbinafine."
24119181