IndraLab

Statements

KCNH2 activates terbinafine. 6 / 6
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"Overexpression of ERG1 increases resistance to terbinafine."
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"Under both conditions of iron‐sufficiency and iron‐depletion, ERG1 overexpression increased terbinafine resistance, as it resulted in higher IC80 values (Figure 2C, S2B)."
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"Highest squalene levels (over 1000mug squalene per 10 (9) cells) were induced by specific point mutations in ERG1 gene that reduced activity of squalene epoxidase and caused hypersensitivity to terbinafine."
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"In general, Erg1 downregulation by iron chelation causes an increase in terbinafine susceptibility, although the degree of susceptibility varies among the strains."
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"Terbinafine targets ERG1, which is the upstream gene for ERG11, the target for posaconazole."
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"The squalene monooxygenase (LINF_130021700; ERG1) and C8 sterol isomerase (LINF_290029100; ERG2) genes respectively encoded on the cosmids derived from chromosomes 13 and 29 (Table 1) were the most likely candidates for producing TBF resistance, as both are involved in the ergosterol biosynthesis pathway (Fig. 1).3.3 Overproduction of the squalene monooxygenase gene ERG1 produces terbinafine resistance."
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