IndraLab

Statements

USP38 binds SLC16A1. 4 / 4
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"Co-immunoprecipitation and ubiquitination assays were conducted to analyze the interaction between USP38 and MCT1, as well as the regulation of MCT1 deubiquitination."
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"To further validate this interaction, we performed a Co‐IP assay, which confirmed the binding between USP38 and MCT1 (Figure 4B,C)."
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"This study demonstrated that USP38 interacts with the monocarboxylate transporter MCT1 (SLC16A1), deubiquitinates MCT1 to enhance its expression, and thereby promotes lactate efflux under PM2.5 exposure."
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"However, direct evidence supporting an interaction between USP38 and MCT1 remains to be established."
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