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Amitriptyline inhibits CASP1. 3 / 3

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"Amitriptyline did not attenuate caspase-1 activation upon stimulation with NLRP3 activating LPS and ATP and LPS and nigericin treatments in mouse mixed glial cells (XREF_FIG)."

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"Thus, we examined whether the antidepressant amitriptyline impairs NLRP3 dependent caspase-1 activation."

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"Antidepressant Amitriptyline Does Not Inhibit NLRP3 Dependent Caspase-1 Activation but Suppresses LPS Triggered IL-1beta mRNA Production."

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Amitriptyline inhibits CASP1. 3 / 3

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