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BAP1 binds KLF5. 32 / 32
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"The deubiquitinase (DUB) BAP1 had been reported to regulate KLF5 stability in breast cancer cells, so we hypothesize that LINC00152 mediates KLF5 depending on the binding of BAP1 and KLF5."
33842324
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"As shown in XREF_SUPPLEMENTARY, LINC00152 knockdown inhibits BAP1 binding with KLF5."
33842324
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"Another KLF5 DUB that stood out in siRNA screening was BAP1 (BRCA1-associated protein 1), which also directly binds KLF5 and stabilizes KLF5 through deubiquitination [ xref ]."
27844253
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"The deubiquitinase (DUB) BAP1 had been reported to regulate KLF5 stability in breast cancer cells ( xref , xref ), so we hypothesize that LINC00152 mediates KLF5 depending on the binding of BAP1 and KLF5."
33842324
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"As shown in xref , LINC00152 knockdown inhibits BAP1 binding with KLF5."
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"Another KLF5 DUB that stood out in siRNA screening was BAP1 (BRCA1 associated protein 1), which also directly binds KLF5 and stabilizes KLF5 through deubiquitination [XREF_BIBR]."
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"LncRNA PVT1 enhanced KLF5 protein stability by increasing the interaction between KLF5 and the deubiquitinase BAP1 [ 26 ]."
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"BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination."
26419610
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"BAP1 interacts directly with KLF5."
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"Recently, Jia et al. ( xref ) showed that the WWP1- BAP1-KLF5 axis is dysregulated in melanoma cancer; WWP1 was lowly expressed in melanoma cells and tissues whereas KLF5 and BAP1 were highly expressed and closely related to tumor metastasis."
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"These results indicated that BAP1 directly interacts with KLF5 and stabilizes KLF5 as well."
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"After these mutants were expressed in HEK293FT cells together with GST-BAP1, we pulled down GST-BAP1 with glutathione beads and found that full-length KLF5 (1-457), the KLF5 N terminus (1-200, 1-372) and the KLF5 C terminus (373-457, 201-457) interacted with BAP1."
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"Taken together, these results suggest that BAP1 directly interacts with KLF5 and that the interaction is mediated by the N- and C termini of BAP1 and KLF5."
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"Because KLF5 interacted with BAP1 directly, we wondered whether KLF5 was in the BAP1 and HCF -1 complex."
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"First, BAP1 interacts with KLF5 directly."
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"Finally, the interaction between BAP1 and KLF5, a transcription factor implicated in various biological processes including cell proliferation and differentiation, further underscores BAP1’s role in regulating cellular functions xref , xref ."
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"Qin et al. reported that BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination and the KLF5/BAP1/HCF-1 complex promoted the tumorigenesis and lung metastasis of breast cancer by inhibiting p27 gene expression [37]."
37322017
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"BAP1 interacted with KLF5 and led to its stability and exerted its oncogenic function in breast cancer."
34226507
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"A recent study showed that BAP1 forms a complex with the transcription factor KLF5 to stimulate cell cycle progression and promotes breast cancer cell proliferation by deubiquitinating and stabilizing KLF5 xref ."
36754982
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"A recent study showed that BAP1 forms a complex with the transcription factor KLF5 to stimulate cell cycle progression and promotes breast cancer cell proliferation by deubiquitinating and stabilizing KLF5 ."
36754982
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"Finally, the interaction between BAP1 and KLF5, a transcription factor implicated in various biological processes including cell proliferation and differentiation, further underscores BAP1’s role in regulating cellular functions ."
39191942
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"These results indicated that BAP1 directly interacts with KLF5 and stabilizes KLF5 as well.Then we investigated whether BAP1 affected the degradation of KLF5 by WWP1."
33516665
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"These evidence indicated that the BAP1-WWP1 axis in melanoma played an important role in regulating the function of KLF5.In this study, we verified by Co-IP that either BAP1 or WWP1 bound directly to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33516665
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"That BAP1 interacts with KLF5 is of potential interest."
31903168
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"Qin et al. reported that BAP1 interacts directly with KLF5 and stabilizes KLF5 via deubiquitination and the KLF5/BAP1/HCF-1 complex promoted the tumorigenesis and lung metastasis of breast cancer by inhibiting p27 gene expression [ xref ]."
37322017