IndraLab

Statements

USP19 activates CFTR. 4 / 4
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"In preceding studies the ER localised USP19 was shown to rescue the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation 109."
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"Interestingly, USP19 is a target gene of the unfolded protein response (UPR) and was found to rescue CFTR DeltaF508 from ERAD."
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"USP19 was reported to rescue the CFTR Delta508 mutant, which is an ERAD substrate."
27751231
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"USP19 rescues the ERAD substrates cystic fibrosis transmembrane conductance regulator (CFTR) DeltaF508 and T-cell receptor-alpha (TCRalpha) from proteasomal degradation."
19465887