IndraLab

Statements


OTUB1 inhibits IL6. 3 / 3
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"Overexpression of OTUB1 inhibited mRNA levels of chemokine MCP-1 as well as IL-6 ( Fig. 5 C)."

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"As shown in Fig. 2a, b, OTUB1-deficient BMDCs produced significantly less IL-12, TNF, and IL-6 after stimulation with T. gondii, T. gondii lysate antigen (TLA), TgPFN (which all signal via MyD88 ) (Fig. 2a), and LPS (Fig. 2b)."

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"OTUB1 also inhibited TNFα-induced IL-6 gene and protein expression in U937 cells, a human macrophage-like cell line ( Fig. 5 G & H)."