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USP22 activates FOXM1. 4 / 4
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"The result of GSIS assay further indicated that overexpressing USP22 could rescue the insulin secretion ability of INS-1 cells that was impaired by HG; but miR-144-3p mimic abated this impact (Fig. 4H)."
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"Mechanistically , it has been reported that USP22 induces beta-catenin nuclear localisation and upregulates FoxM1 expression to promote G1 / S cell cycle transition and cell proliferation ( Ning et al ., 2014 ) ."
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"In concordance with this conclusion, USP22 overexpression dramatically prolonged FoxM1 half-life as measured by pulse-chase analysis (Fig. 3J & 3K)."
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"In pancreatic cancer cell lines a different mechanism in USP22 was found to modulate the lacatenin/Wnt signaling and therefore increase the abundance of FoxM1, a transcription factor that normally represses the expression of p21 and p27."
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