IndraLab

Statements

Tamoxifen inhibits KCNH2. 11 / 11
3 | 1 6 1
ctd
No evidence text available
15272206
reach
"It is worth recalling here that Tamoxifen (one of the most used drugs for BC treatment) was shown to block hERG1 currents [XREF_BIBR], a fact that could explain the QT interval elongation observed in Tamoxifen treated patients."
26339650
ctd
No evidence text available
28551711
eidos
"Long ago , it was demonstrated that Kv11.1 current was inhibited by tamoxifen ( Thomas et al ., 2003 ) and more recently it was shown that such inhibition is actually due to the active metabolite of tamoxifen , named endoxifen ( Chae et al ., 2015 ) ."
32508650
reach
"These results indicated that tamoxifen and endoxifen inhibited the hERG current by direct channel blockage and by the disruption of channel trafficking to the plasma membrane in a concentration dependent manner."
25680947
sparser
"Long ago, it was demonstrated that Kv11.1 current was inhibited by tamoxifen ( xref ) and more recently it was shown that such inhibition is actually due to the active metabolite of tamoxifen, named endoxifen ( xref )."
32508650
reach
"Tamoxifen and endoxifen inhibited the hERG channel protein trafficking to the plasma membrane in a concentration dependent manner with endoxifen being more potent than tamoxifen."
25680947
ctd
No evidence text available
21362439
reach
"This study demonstrates that HERG potassium channels are blocked by the antiestrogenic drug tamoxifen."
12827215
reach
"Tamoxifen and endoxifen inhibited hERG tail currents at -50 mV in a concentration dependent manner with IC50 values of 1.2 and 1.6 muM, respectively."
25680947
reach
"Tamoxifen blocked HERG potassium channels with an IC (50) value of 45.3 microM."
12827215