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AR activates KCNQ1. 11 / 11
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"Possible involvement of the C-terminal PY motif, YXXΦ motif and PKC phosphorylation sites in α 1 AR-induced KCNQ1 internalization was investigated using the KCNQ1 mutants."
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"Furthermore, dynasore, a dynamin inhibitor, attenuated α 1 AR-mediated internalization of KCNQ1."
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"Representative images of Halo-KCNQ1 localization before and after PE application showed that activation of α 1A AR and α 1B AR caused KCNQ1 internalization in the presence of 10 −6 M BIS-I ( Fig. 6 A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, when quantified using TB, the α 1 AR-induced KCNQ1 internalization was not markedly but significantly smaller in the presence of BIS-I or calphostin C than in its absence ( Fig. 6 C and D)."
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"However, overexpression of α 1 AR was required to induce KCNQ1 internalization in our experimental conditions."
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"However, in the case of dynasore, TB treatment hardly quenched the membrane fluorescence ( Fig. 6 C and D), which reflects the involvement of dynamin in the α 1 AR-induced KCNQ1 internalization as des[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, further studies are necessary to clarify the α 1 AR-induced KCNQ1 internalization and its physiological meaning in native tissues.In summary, we demonstrate KCNE1-independent internalizatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although mechanisms by which α 1 AR activation induces direct KCNQ1 internalization are still not completely understood, we think that it is AP2/clathrin-dependent and likely triggered by ubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our pharmacological experiments using BIS-I and calphostin C in cells expressing KCNQ1 (without KCNE1) suggest that PKC is at least partly involved in α 1 AR-induced KCNQ1 internalization."
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"We found that α 1 AR stimulation caused internalization of KCNQ1 irrespective of KCNE1 expression."
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"As described below, we subsequently quantified the α 1 AR-induced KCNQ1 internalization at 60 min after PE application using trypan blue (TB) ( Sections 3.3 and 3.4 )."
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