IndraLab

Statements

AR activates KCNQ1. 3 / 3
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"Our results suggest that alpha 1 AR mediated direct internalization of KCNQ1 is AP2 and clathrin dependent and may be triggered by ubiquitination of KCNQ1 via the AMP dependent kinase (AMPK)/Nedd4-2 pathway."
31491415
reach
"Activation of alpha 1A AR and alpha 1B AR caused marked internalization of KCNQ1, which was not KCNE1 dependent."
31491415
reach
"Because we have observed down-regulation of KCNQ1 and KCNE1 currents by activation of the alpha 1 -adrenergic receptor (alpha 1 AR) that activates PKC, this study investigated whether alpha 1 AR causes internalization of the KCNQ1 protein."
31491415