IndraLab

Statements

Mutated BAP1 activates 2'-O-methyluridine. 4 / 4
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"Regarding tumor mutation, we discovered that BAP1 was more frequently mutated in the Cluster1 subtype, which was consistent with prior evidence suggesting BAP1 mutations enhance the possibility of UM patients developing metastases [32]."
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"BAP1 mutations enhanced the malignant phenotypes of UM cells."
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"Herein, we set out to investigate whether BAP1 mutations could regulate the development in UM, and our results demonstrated that BAP1 mutations could induce the tumor immune microenvironment in UM by inactivating the NF-κB signaling pathway."
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"BAP1 is a high-risk locus in UM and germline BAP1 mutations increase the risk of developing UM and other tumours such as melanocytic skin tumours, mesothelioma, and renal cell carcinoma (known as the BAP1-predisposition syndrome) [8,174]."
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