IndraLab

Statements

OTUB1 binds RAS. 4 / 5
| 1 3
sparser
"Using a set of reciprocal immunoprecipitations, we confirmed that OTUB1 interacted with RAS proteins (Fig  xref C–F)."
26881969
reach
"Consistently with this observation, both inactive GDP bound and active GTP-gamma-S-bound forms of NRAS interacted with OTUB1 (Fig XREF_FIG E), indicating that GTP binding does not significantly affect the interaction between RAS and OTUB1."
26881969
sparser
"Consistently with this observation, both inactive GDP‐bound and active GTP‐γ‐S‐bound forms of NRAS interacted with OTUB1 (Fig  xref E), indicating that GTP binding does not significantly affect the interaction between RAS and OTUB1."
26881969
sparser
"These results strongly indicate that OTUB1 interacts with RAS proteins in a GTP‐independent manner, suggesting that OTUB1 is an upstream regulator of RAS GTPases."
26881969