IndraLab

Statements

ASXL proteins binds BAP1. 3 / 3
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"The interaction between BAP1 and the ASXL proteins is mediated by the ~ 120-residue DEUBAD (DEUBiquitinase ADaptor) domain of the ASXL proteins [XREF_BIBR], and this region is sufficient for activation of BAP1 in in vitro H2AK119ub1 nucleosome deubiquitination assays [XREF_BIBR]."
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"The ASXL proteins directly interact with BAP1, KDM1A, NHRs and NCOA1 to target specific genomic loci using histone modifications."
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"ASXL proteins interact with BAP1 to form the polycomb repressive deubiquitinase (PR-DUB) complex, which removes monoubiquitin from histone 2A at lysine 119 (H2AK119) [XREF_BIBR, XREF_BIBR]."
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