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CYLD inhibits positive regulation of NF-kappaB transcription factor activity. 2 / 2

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"CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-kappaB activation."

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"Loss of Cyld expression was shown to enhance NFkappaB activation both in unstimulated conditions and in response to TNF and CD40 ligands [ 220,221 ] , caused by the increase in M1 - and K63-linked ubiquitination of components of the TNFR1 signaling complex [ 189,218 ] ."

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IndraLab

Statements

CYLD inhibits positive regulation of NF-kappaB transcription factor activity. 2 / 2

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