Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD inhibits positive regulation of NF-kappaB transcription factor activity. 2 / 2

| 1 1

➶

reach

"CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-kappaB activation."

30285829

➶

eidos

"Loss of Cyld expression was shown to enhance NFkappaB activation both in unstimulated conditions and in response to TNF and CD40 ligands [ 220,221 ] , caused by the increase in M1 - and K63-linked ubiquitination of components of the TNFR1 signaling complex [ 189,218 ] ."

33808506

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...