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KCNH1 activates Cyclin. 2 / 2
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"In addition, selective inhibition of Eag1 significantly decreased the expression levels of cyclin D1 and E. Taken together, our data suggest that the Eag1 channel plays a crucial role in regulating the proliferation and cell cycle of osteosarcoma cells, and represents a new and effective therapeutic target for osteosarcoma."
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"Moreover, the effect of hEag1 channel inhibition is accompanied by a decrease of cyclin E expression, the key regulator of the G1/S transition and necessary for the entry of cells into S phase.Astemiz[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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