IndraLab

Statements

reach
"Although in HeLa cells silencing USP8 promotes death receptor-mediated extrinsic apoptosis (47), here we found that USP8 affects apoptosis in PCa via modulating the intrinsic apoptosis pathway, and its influence on extrinsic apoptosis in PCa is needed to be investigated more in the future.EGFR has been studied as a potential target in various solid cancers, including lung, bladder, colon, breast, and head and neck carcinomas."
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reach
"USP8 can directly remove ubiquitination and inhibit exogenous apoptosis by stabilizing FLIPL, a death receptor that regulates apoptosis [18] ."
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