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OTUB1 activates RIGI. 10 / 10
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"After IAV infection, OTUB1 has been observed to translocate from the nucleus to the mitochondrial membrane and subsequently activate RIG-1 through deubiquitination and E2 suppression, thereby triggering RIG-1-dependent immune signaling and antiviral responses [ xref ]."
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"The RIG-I tetramer translocates to mitochondrial membrane, where it activates downstream effectors including IRF3, IRF7, and NF-kB to produce type-I Interferon (IFN-I) ( xref ). xref found OTUB1 activates RIG-I at mitochondria and achieves this function through both DUB activity and E2-blocking activity."
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"Jahan et al. (2020) found OTUB1 activates RIG-I at mitochondria and achieves this function through both DUB activity and E2-blocking activity."
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"After IAV infection, OTUB1 has been observed to translocate from the nucleus to the mitochondrial membrane and subsequently activate RIG-1 through deubiquitination and E2 suppression, thereby triggering RIG-1-dependent immune signaling and antiviral responses [32]."
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"Collectively, our results indicate that OTUB1 deficiency inhibits NF-κB and IRF activities, suggesting that it acts upstream of these transcription factors in the RIG-I signaling cascade."
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"OTUD1 inhibits innate antiviral immunity in response to RNA and DNA viruses ( Zhang et al., 2018 , 2020b , 2020c ), OTUD4 promotes antiviral response by deubiquitinating and stabilizing MAVS ( Liuyu e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, our data indicate that OTUB1-dependent activation of RIG-I is impeded by the presence of IAV NS1 by facilitating its proteasomal degradation."
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"Collectively, our data indicate that OTUB1-dependent activation of RIG-I is impeded by the presence of IAV NS1 by facilitating its proteasomal degradation.RLRs are critical cytosolic sensors for patho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine the mechanism of OTUB1-dependent RIG-I activation, we adopted a cell-free system of IRF3 dimerization ( Zeng et al., 2010 ) reconstituted from purified RIG-I, mitochondria, and cytosol ex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data suggest that OTUB1 participates by a dual mechanism to enable RIG-I activation; first via its conventional deubiquitylating activity and also by inhibition of E2 enzymes, most likely Ubch5c, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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