IndraLab

Statements

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"LPS induces USP13 degradation by the ubiquitin-proteasome system in Kupffer cells.."
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"MG-132, but not leupeptin, attenuated LPS-induced USP13 degradation (Fig. 4B–D)."
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"Inhibition of JNK had no effect on LPS reduction of USP13 in Raw264.7 cells, while JNK inhibitor attenuates USP13 degradation in Kupffer cells."
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"Inhibition of proteasome, but not lysosome or immunoproteasome, attenuates LPS-induced USP13 degradation, suggesting USP13 degradation is mediated by the ubiquitin-proteasome system."
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"Inhibition of NF-κB, JNK, and p38 had no effect on LPS-induced USP13 reduction (L. Li et al., 2019)."
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"However, in contrast to USP13 mRNA changes in Raw264.7 cells, LPS reduces USP13 stability, but not mRNA levels, in Kupffer cells."
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"LPS induces USP13 degradation by the ubiquitin-proteasome system in Kupffer cells ."
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"LPS diminishes USP13 levels , but not USP13 mRNA , in Kupffer cells ."
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"Catalytic activity of USP13 is not necessary for LPS-reduced USP13.."
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"Thus, catalytic activity of USP13 is a minor factor for regulating its half-life, while it is not necessary for LPS-induced USP13 degradation."
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"As shown above, LPS induced USP13 degradation in 24 h, but not in a shorter time exposure (4 and 8 h)."
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"Inhibitors of DNA methylation (5-azacytidine) and histone methylation (BIX-01294) had no effect on LPS-induced USP13 reduction (Fig. 7A–C)."
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"It has reported that lipopolysaccharides (LPS) reduces USP13 stability via ubiquitin-proteasome degradation pathway in Kupffer cells [35]."
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"The effect of JNK inhibitor II on LPS-induced USP13 degradation was confirmed by an experiment using increasing doses of the inhibitor (Fig. 7E)."
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"This data suggests that LPS induces synthesis of a USP13 degrading protein through activation of JNK in Kupffer cells."
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"Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells."
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"LPS reduces USP13 protein stability, not transcription, in kupffer cells."
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"As shown above , LPS induced USP13 degradation in 24 h , but not in a shorter time exposure ( 4 and 8 h ) ."
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