IndraLab

Statements

HIF1A binds USP9X. 7 / 7
2 | 5
sparser
"The most potent inhibitor VH298 ( 2 ) exhibited VHL inhibitory activity values of 80 nM ( K d ), 18.9 nM ( K i ), and 110.4 nM ( K i ) in the FAM–HIF–1α peptide (19 mer)-mediated FP assay, BODIPY FL VH032 ( 5 )-mediated TR-FRET assay, and FP assay, respectively."
33458521
sparser
"For VH298 ( 2 ) activity, our BODIPY FL VH032 ( 5 )-based TR-FRET assay was more sensitive (4.23-fold) than the FAM–HIF–1α peptide (19 mer)-based FP assay."
33458521
sparser
"However, our BODIPY FL VH032 ( 5 )-based FP assay exhibited comparable sensitivity with the previously reported FP assay with the FAM–HIF–1α peptide (19 mer)."
33458521
biogrid
No evidence text available
34592152
biogrid
No evidence text available
34592152
sparser
"NANOG-KD abrogated the interaction of USP9X with HIF-1α ( Figure 4 E)."
34592152
sparser
"We next tested the three VHL ligands VH032 ( 1 ), VH298 ( 2 ), and BOC-VH032 ( 8 ) using our new BODIPY FL VH032 ( 5 )-based TR-FRET and FP assays and compared the activities with those from the reported FAM–HIF–1α peptide (19 mer)-based FP assay xref ( xref )."
33458521