IndraLab

Statements

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"LPS induced Stat1 activation was diminished in Ahr KO macrophages compared with that in WT cells (XREF_FIG)."
19703987
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"In LPS-activated J774A.1 macrophages, BS showed anti-inflammatory effect through inactivating STAT1 and NF-κB signal transduction (Valerio and Awad 2011)."
30905278
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"The current data indicate that NaN 3 pretreatment of macrophage like cell lines resulted in the suppression of LPS induced activation of STAT1 and IkappaBzeta without affecting NF-kappaB activation."
28391993
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"In other studies, Shirota and co-workers reported that blockade of STAT1 phosphorylation using synthetic oligonucleotides confers resistance to LPS induced injury whereas Kim et al demonstrated that LPS induced production of the pro inflammatory mediator HMGB1 is attenuated in STAT1 deficient mice."
22777121
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"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."
22925925
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"It was possible that apoptotic cells induced expression of soluble or intracellular factors that suppressed LPS-induced STAT1 activation."
17349870
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"We reported that CBD reduces the activity of the NF-kappaB pathway and upregulates the activation of STAT3 transcription factor in LPS stimulated BV-2 cells, and that both CBD and THC decrease the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent pro inflammatory processes XREF_BIBR."
23637839
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"Thus, in contrast to HF 's AAR activation in T cells, the mode of action of halofuginone in primary macrophages is marked by an activation of NFkappaB and a disruption of LPS induced STAT1 activation."
27211859
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"As expected, LPS stimulated IgM production and Prdm1 expression were significantly lower in the Stat1 knockdown cells compared with the luciferase knockdown control (XREF_FIG)."
27849553
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"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."
27488844
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"In contrast, tryptanthrin increased the LPS-induced expression of ISGs compared to the vehicle (Fig. 3C), indicating that tryptanthrin selectively attenuates TLR3-specific STAT1 signaling in THP-1 Mϕ."
35666435
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"As previously reported, Catalpalactone can inhibit the NO synthase (iNOS) expression and the production of NO, IL6 and tumor necrosis factor-α in the lipopolysaccharide-induced macrophage, and regulate the anti-inflammatory signaling, such as inhibiting STAT-1, IFN-β and IRF3 activation, to play a cytoprotecting role [21]."
39940010
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"BTXA resisted the M1 polarization of macrophages induced by LPS via deactivating the JAK2/STAT1 and IκB/NFκB pathways."
38518603
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"These results showed that ACT001 might suppress LPS-induced M1 polarization and inflammation through inhibiting both NF-κB and STAT1 signaling pathways."
35728304
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"Western blotting revealed that LPS induced activation of STAT1 and STAT5 in macrophages was significantly inhibited by CopA3."
22969062
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"As observed when BMDCs were treated with LPS, LPS pre-treatment of BMDMs inhibited the Stat1 response to IFNalpha and IL-6, but not IFNgamma (XREF_FIG)."
19494279
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"However, both CBD and THC decreased the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent proinflammatory processes."
19910459
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"Our immunofluorescence results in Fig. 7A-C suggested that the fluorescence intensity of BST2 and STAT1 in LPS group and LPS + DMSO group were lower than that in control group and LPS + AKBA group, and that LPS induction may inhibit nuclear metastasis and cytoplasmic punctate aggregation of STAT1, while AKBA treatment effectively promoted STAT1 nuclear entry and cytosolic deaggregations."
40307322
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"Consequently, we observed that NAC application led to a reduction of LPS-mediated STAT1 activation (Figures 5B, C)."
34777396
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"In our study, HPBD inhibition of LPS induced STAT1 and STAT3 activity in astrocytes and microglial BV-2 cells."
23891616
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"In a human leukemia cell line THP-1, tipifarnib inhibited lipopolysaccharide (LPS)-induced transcription of chemokines [monocyte chemotactic protein (MCP) -1 and MCP-2], cytokines [interleukin (IL)-1beta, IL-6, and interferon (IFN) beta], signaling molecules (MyD88 and STAT-1), proteases [matrix metalloproteinase (MMP-9)], and receptors (urokinase receptor)."
16352705
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"Our results revealed that in n-6 mice, LPS induced STAT1, STAT3 and JAK2 activation was also attenuated as compared to n3/n -6 mice."
18973601
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"Melatonin inhibits Prevotella intermedia lipopolysaccharide induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity."
21158907
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"Consistent with impaired LPS-induced STAT-1 signaling in the neonatal lung, we found significantly lower iNOS expression when compared to similarly exposed adults (Figure 4J)."
30319651
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"LPS induced lung injury was attenuated in STAT1 knockout mice."
22450807
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"Importantly, LPS-induced STAT1 activation is completely inhibited by the NFκB inhibitor BAY 11–7085 (Figure 5B), likely due to impaired NFκB-regulated IFNβ expression (Figure 3E)."
30319651
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"LPS Inhibits the JAK2/STAT1 Signaling Pathway."
39769435
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"Collectively, these data suggested that aloin attenuated the LPS triggered inflammatory response by suppressing STAT1 and STAT3 activation, but not MAPKs, IKK or IkappaB."
30066904
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"It has been reported that LPS stimulation induces suppressor of cytokine signalling 3 (SOCS3) expression and the overexpression of SOCS3 inhibits signal transducer and activator of transcription 1 (STAT1) and janus kinase 1 (JAK1) activation in macrophages treated with IFNgamma 20."
31793076
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"In the LPS-induced murine ALI model, exosomal miR-7704 from MSCs evokes M2 polarization in lung macrophages by inhibiting the MyD88/STAT1 signaling pathway, thereby restoring pulmonary function and increasing survival (18)."
39840035
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"LPS (TLR4 signaling) administration to macrophages induced integrin beta3 activation and enhanced STAT1 signaling; disruption of integrin beta3 (such as beta3KOM) diminished this enhancement of STAT1 signaling."
27216180
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"For example, Maiuri et al. [17] reported that HT suppresses LPS-induced NF-κB activation as well as the LPS-induced activation of STAT1 and its downstream signaling molecule interferon regulating fact[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24680823
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"However, LPS did not significantly alter the p-JAK2/T-JAK2 ratio on d12, d16, and d20 (Figure 3B–D), indicating that LPS infusion inhibited the JAK2/STAT1 signaling pathway."
39769435
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"Taken together, these data indicate that LPS infusion disrupts the endometrial receptivity of sheep by inhibiting the JAK2/STAT1 signaling pathway."
39769435
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"It was reported that LPS induced STAT1 activation was inhibited by quercetin in combination with its profound inhibitory effects on iNOS and NF-kappaB expression, which are persistently involved in activation of interleukin-2 (IL-2) as shown in XREF_FIG [XREF_BIBR]."
27589790
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"Finally, to test the possibility that down-regulation of IFN-R by A2 results in reduction of LPS-induced STAT1 activation, we examined whether A2 suppresses expression of IFN-R."
21856162
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"Absence of Tyk2 strongly reduces LPS mediated Stat1 activation, as well as delays the onset and shortens the duration of the response."
11070173
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"In the current study, 3′-SL inhibited LPS-induced mRNA expression of VCAM-1 upregulation through suppressing STAT1 activation ( Figs."
38191050
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"Like live bacteria, LPS inhibited the ability of Stat1 to respond to multiple stimuli in T cells and macrophages in a dose dependent manner (XREF_FIG)."
19494279
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"The inhibitory effect of CORM-3 on LPS-induced STAT1 activation has not been reported previously."
26101061
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"We postulate that KPG might involve in weak reduction of LPS induced STAT1 (Ser 727) instead of p38."
29470957