IndraLab

Statements

reach
"Consistent with impaired LPS-induced STAT-1 signaling in the neonatal lung, we found significantly lower iNOS expression when compared to similarly exposed adults (Figure 4J)."
30319651
reach
"Western blotting revealed that LPS induced activation of STAT1 and STAT5 in macrophages was significantly inhibited by CopA3."
22969062
reach
"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."
27488844
reach
"In a human leukemia cell line THP-1, tipifarnib inhibited lipopolysaccharide (LPS)-induced transcription of chemokines [monocyte chemotactic protein (MCP) -1 and MCP-2], cytokines [interleukin (IL)-1beta, IL-6, and interferon (IFN) beta], signaling molecules (MyD88 and STAT-1), proteases [matrix metalloproteinase (MMP-9)], and receptors (urokinase receptor)."
16352705
reach
"Melatonin inhibits Prevotella intermedia lipopolysaccharide induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity."
21158907
reach
"It has been reported that LPS stimulation induces suppressor of cytokine signalling 3 (SOCS3) expression and the overexpression of SOCS3 inhibits signal transducer and activator of transcription 1 (STAT1) and janus kinase 1 (JAK1) activation in macrophages treated with IFNgamma 20."
31793076
reach
"Our results revealed that in n-6 mice, LPS induced STAT1, STAT3 and JAK2 activation was also attenuated as compared to n3/n -6 mice."
18973601
reach
"Thus, in contrast to HF 's AAR activation in T cells, the mode of action of halofuginone in primary macrophages is marked by an activation of NFkappaB and a disruption of LPS induced STAT1 activation."
27211859
reach
"However, both CBD and THC decreased the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent proinflammatory processes."
19910459
reach
"LPS (TLR4 signaling) administration to macrophages induced integrin beta3 activation and enhanced STAT1 signaling; disruption of integrin beta3 (such as beta3KOM) diminished this enhancement of STAT1 signaling."
27216180
reach
"As observed when BMDCs were treated with LPS, LPS pre-treatment of BMDMs inhibited the Stat1 response to IFNalpha and IL-6, but not IFNgamma (XREF_FIG)."
19494279
reach
"Collectively, these data suggested that aloin attenuated the LPS triggered inflammatory response by suppressing STAT1 and STAT3 activation, but not MAPKs, IKK or IkappaB."
30066904
reach
"Absence of Tyk2 strongly reduces LPS mediated Stat1 activation, as well as delays the onset and shortens the duration of the response."
11070173
reach
"It was reported that LPS induced STAT1 activation was inhibited by quercetin in combination with its profound inhibitory effects on iNOS and NF-kappaB expression, which are persistently involved in activation of interleukin-2 (IL-2) as shown in XREF_FIG [XREF_BIBR]."
27589790
reach
"In other studies, Shirota and co-workers reported that blockade of STAT1 phosphorylation using synthetic oligonucleotides confers resistance to LPS induced injury whereas Kim et al demonstrated that LPS induced production of the pro inflammatory mediator HMGB1 is attenuated in STAT1 deficient mice."
22777121
reach
"In LPS-activated J774A.1 macrophages, BS showed anti-inflammatory effect through inactivating STAT1 and NF-κB signal transduction (Valerio and Awad 2011)."
30905278
reach
"Consequently, we observed that NAC application led to a reduction of LPS-mediated STAT1 activation (Figures 5B, C)."
34777396
reach
"Importantly, LPS-induced STAT1 activation is completely inhibited by the NFκB inhibitor BAY 11–7085 (Figure 5B), likely due to impaired NFκB-regulated IFNβ expression (Figure 3E)."
30319651
reach
"We postulate that KPG might involve in weak reduction of LPS induced STAT1 (Ser 727) instead of p38."
29470957
reach
"The current data indicate that NaN 3 pretreatment of macrophage like cell lines resulted in the suppression of LPS induced activation of STAT1 and IkappaBzeta without affecting NF-kappaB activation."
28391993
reach
"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."
22925925
reach
"As expected, LPS stimulated IgM production and Prdm1 expression were significantly lower in the Stat1 knockdown cells compared with the luciferase knockdown control (XREF_FIG)."
27849553
reach
"LPS induced Stat1 activation was diminished in Ahr KO macrophages compared with that in WT cells (XREF_FIG)."
19703987
reach
"However, it showed a significant inhibitory effect on LPS induced activation of STAT1 and STAT3 proteins in macrophages."
28778215
reach
"LPS induced lung injury was attenuated in STAT1 knockout mice."
22450807
reach
"We reported that CBD reduces the activity of the NF-kappaB pathway and upregulates the activation of STAT3 transcription factor in LPS stimulated BV-2 cells, and that both CBD and THC decrease the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent pro inflammatory processes XREF_BIBR."
23637839
reach
"In contrast, tryptanthrin increased the LPS-induced expression of ISGs compared to the vehicle (Fig. 3C), indicating that tryptanthrin selectively attenuates TLR3-specific STAT1 signaling in THP-1 Mϕ."
35666435
reach
"Like live bacteria, LPS inhibited the ability of Stat1 to respond to multiple stimuli in T cells and macrophages in a dose dependent manner (XREF_FIG)."
19494279