IndraLab

"Furthermore, research has revealed that HCMV encodes UL7 protein, which serves homology to the N-terminal V-like domain of carcinoembryonic antigen-related cell adhesion molecule 1 (CEA-CAM1), a pro-angiogenic factor involved in signal transduction and cellular adhesion."

"To assess the selectivity of the immunosensing platform and ensure that the change in the current is due to antigen binding and not the settling of proteins on the surface, a test of some compounds that may be in negative controls of real samples was conducted, including bovine serum albumin (BSA), carcinoembryonic antigen (CEA-CAM), prostate-specific antigen (PSA), 20S proteasome, ascorbic acid (AA), glucose, and dopamine."

"Contaminating cells, for example inhibitory NK cells [ 27 ], γδ T cells [ 28 ], factors such as CEA-related cellular adhesion molecule-1 (CEA-CAM 1) [ 29 ] and cytokines such as TGFβ [ 30 ], have been[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Our scope, once again, is GPI anchored CEAs: CEA-CAM 6 and CEA-CAM 5, which is also known as CD66e ( xref )."

"CEA-CAM 1 is tumor suppressing through decreasing cell proliferation and metastasis, while CEA-CAM-5 is tumor promoting through inhibiting colon cell differentiation, anoikis and apoptosis ( xref , xref )."

"CEA-CAM 6 oncogenic activity is due to mediating metastasis and resisting apoptosis."

"Increasing metastasis is through CEA-CAM 6 signaling induced SRC activity."

"Carcinoembryonic antigen-related cell adhesion molecule (CEA-CAM)-positive monocytes are associated with inflammation and ILD in SSc patients [ xref , xref , xref , xref ]."

"This complex translocates to the nucleus and binds to CEA-CAM 6 gene promoter, elevating its expression ( xref )."

"Interestingly, CEA-CAM 1 is under expressed in CRC, breast cancer, prostate cancer and hepatoma ( xref )."

"On the other hand, 70% of epithelial tumors over express CEA-CAM 6 rather than CEA-CAM 5 ( xref , xref , xref )."

"Interestingly, CEA-CAM 5 is temporarily produced during fetal development until birth."

"On the other hand, we identified nine known tumor antigen genes ( ABCC3, CDR2, CEACAM21 , CEA-CAM4, DSE, EPS8, ISG15, MUC1, and TBXT ) whose expression levels correlated with T cell scores (linear regression p values < 0.05)."

"Other CEA-CAM targeting antibodies are MN-3, MN-14 and MN-15."

"In addition, Silencing CEA-CAM 6 by RNAs decreased tumor proliferation by 68% in pancreatic cancer xenograft mice compared to control siRNAs (f."

"Liver metastatic colorectal cancer cells express high levels of various progenitor markers such as EpCAM, CD44, CD24, and CEA-CAM along with CDX1."

"The nanostar–nanostar configuration of the assay was thus able to achieve an LOD in the range of 1 to 3 ng mL −1 for the detection of biomarker carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5)."

"DC-SIGN can bind through carcinoembryonic antigen-related cell adhesion molecule 1 (CEA-CAM1) on neutrophil surface [ xref ] or ICAM-3 on T-lymphocytes [ xref ]."

"In a preliminary study, Ma et al. [ xref ] identified carcinoembryonic antigen-related cell adhesion molecule 1 (CEA-CAM1) and Klotho as biomarkers with high specificity and sensitivity for salivary gland malignant tumors, noting that Klotho expression was downregulated in MEC."

"Serum CA19-9 as the most common clinical biomarker with a sensitivity of 70–80% but specificity less than 50% is currently employed as a treatment efficacy marker for PDAC rather than a diagnostic marker because of its correlation to tumor size and stage. xref , xref Recently, many biomarkers such as CEA, CA242, CA-125, MUC-1, CEA-CAM1, MIC-1, MMP-9, Lectins, REG4, osteopontin, k-ras mutation, and gene methylation were assessed for PDAC diagnosis. xref − xref However, considering both performance and implementation, serum CA19-9, although not satisfying, remains dominant in clinical practice."

"Down‐regulation of miR‐16‐5p and miR‐125b‐3p aggravate intestinal barrier function in IBD‐D patients via targeting claudin‐2 (CLDN2) and cingulin (CGN), respectively. xref miR‐144 increases intestinal permeability in IBS‐D rats via targeting occludin (OCLN) and ZO‐1. xref miR‐200a increases visceral hyperalgesia in IBS‐D rats via targeting cannabinoid receptor 1 (CNR1) and serotonin transporter (SERT). xref miR‐29a‐3p increases intestinal permeability in IBS‐D patients by targeting CLDN1 and nuclear factor‐κB–repressing factor (NKRF). xref miR‐219‐5p regulates intestinal barrier function in IBS‐D by altering the expression of permeability‐associated genes including TJP1/ZO‐1, E‐cadherin (CDH1), carcinoembryonic antigen‐related cell adhesion molecule 5 (CEA‐CAM5), and catenin delta 1 (CTNND1). xref Elucidation of miR‐10b regulation for other tight junction proteins, which are involved in both paracellular and transcellular routes regulating the leaky gut pathway and micro‐anatomical validation of these proteins in colonic tissue of patients with IBS‐C and T2D, warrants further investigation."

"Herein, we propose a sandwich-type surface enhanced Raman scattering (SERS) immuno-nanosensor which is aimed for detecting and quantifying Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5), a protein involved in intercellular adhesion and signaling pathways that acts as a tumor marker in several types of cancer."