IndraLab

Statements

USP9X deubiquitinates TDRD3. 4 / 4
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"To test whether USP9X de-ubiquitinates TDRD3 in cells, we transfected HeLa cells with either control or USP9X specific siRNA, and measured TDRD3 ubiquitination."
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"We observed that when the cellular levels of USP9X were reduced by siRNA, the TDRD3 ubiquitination levels markedly increased (XREF_FIG, upper panel -- compare lane 2 to lane 5) and inhibition of the proteasome greatly augmented this difference (XREF_FIG, upper panel -- compare lane 3 to lane 6), suggesting that USP9X is necessary to suppress TDRD3 ubiquitination."
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"USP9X prevents TDRD3 ubiquitination."
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"USP9X prevents polyubiquitination of TDRD3 in cells."
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