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Wnt activates USP6. 2 / 2

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"Inhibition of Wnt signaling using Dickkopf-1 (DKK1) or a Porcupine (PORCN) inhibitor significantly decreased the growth of USP6 driven xenograft tumors, indicating that Wnt signaling is a key target of USP6 during tumorigenesis."

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reach

"For example, Madan et al. showed that the USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds and inhibition of Wnt signaling significantly decreased the growth of USP6-driven xenograft tumors [20]."

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IndraLab

Statements

Wnt activates USP6. 2 / 2

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