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USP18 activates Mice. 2 / 2
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"Concordantly, lack of USP18 function causes fatal interferonopathies in humans and mice."

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"USP18 expression in B16 melanoma tumor cells modulates immune cell phenotypes, including increasing MHC class-I expression, impairing tumor cell-mediated inhibition of T cell proliferation and activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"