IndraLab

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USP10 increases the amount of SKP2. 9 / 9
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"Moreover, the deubiquitinating activity of USP10 modulates the SKP2 expression and, thus, the activation of BCR–ABL1 signaling."
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"In our study, Co-IP and cycloheximide chase assay verified that USP10 increased SKP2 stability and promoted SKP2 expression."
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"XREF_FIG, only the knockdown of USP10 and USP13 decreased the expression of SKP2."
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"We further found that only USP10-WT, but not USP10-CA, increased the protein level of SKP2, suggesting that deubiquitinating activity of USP10 is required for SKP2 enrichment."
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"As evidenced in Fig. 5B, the overexpression of USP10 upregulated the level of SKP2, and was reduced by USP10 downregulation."
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"We further explored whether USP10 modulates the expression of SKP2 and thus activating Bcr-Abl in CML cells."
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"Immunohistochemistry (IHC) results showed that USP10 inhibition inhibited Skp2 expression in the model of carotid ligation."
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"USP10 increased SKP2 stability and promoted SKP2 expression."
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"Notably, Liao Y et al. reported that ubiquitin-specific peptidase 10 (USP10) could deubiquitinate SKP2 and promote SKP2 expression in chronic myeloid leukemia [21]."
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