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Thioridazine inhibits KCNH2. 11 / 21
4 4 1 | 5 6
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"Thioridazine, perphenazine, trifluoperazine, and chlorpromazine blocked hERG potassium channels with the following IC (50) values : IC (50) values were 224 +/- 42 nM for thioridazine, 1003 +/- 71 nM for perphenazine, 1406 +/- 124 nM for trifluoperazine, and 1561 +/- 281 nM for chloropromazine."
16051556
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"To our best knowledge, no information has been published previously on molecular determinants of I hERG inhibition by thioridazine or other phenothiazine antipsychotic drugs."
17056009
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"This analysis shows that enhancements of endogenous HF oscillations in HR were also found in beagle dogs with dofetilide and with other hERG blockers such as cisapride, haloperidol, risperidone, DL sotalol, terfenadine and thioridazine."
25625756
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"In this investigation, four out of nine hearts developed arrhythmia under hypokalemic conditions, thus supporting the notion that hypokalemia is indeed a risk factor for developing arrhythmia.In addit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16507347
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"Especially, it has been reported that thioridazine and chlorpromazine directly inhibited hERG channels, through which these drugs could induce long QT syndrome [XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR]."
28066143
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"When erythromycin was applied after steady‐state hERG channel block by thioridazine, dofetilide or chloroquine, erythromycin superfusion was associated with a potentiation of hERG block suggesting independent actions."
32147975
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"Especially, it has been reported that thioridazine and chlorpromazine directly inhibited hERG channels, through which these drugs could induce long QT syndrome [ xref xref xref xref ]."
28066143
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"In an extensive study it was shown that a number of potent direct blockers such as bepridil and thioridazine also inhibit hERG trafficking ( Wible et al., 2005 )."
23538024
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"Figure xref shows the concentration dependence of I hERG inhibition by erythromycin, terfenadine and thioridazine under the recording conditions of this study, with representative traces of effects of single drug concentrations shown in Figure xref i–ci and concentration–response relations shown in Figure xref ii–cii."
32147975
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"Figure xref shows the effects of a 15‐min preincubation with 3 µM erythromycin on the concentration dependence of I hERG inhibition by terfenadine and thioridazine, with representative traces of effects of single drug concentrations shown in Figure xref i–bi and concentration–response relations shown in Figure xref ii–bii."
32147975
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"The IC 50 for I hERG tail inhibition by thioridazine in the presence of erythromycin was 46.4 nM (CI 36.3–59.3 nM; n  = 4 to 6 cells per concentration; n H  = 0.73 [CI 0.58–0.90]) which does not differ from the calculated IC 50 value for I hERG inhibition in the absence of erythromycin as represented by the respective overlapping concentration–response curves in Figure xref ii ( p  > ."
32147975