IndraLab
Statements
Thioridazine inhibits KCNH2. 18 / 19
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sparser
"Figure xref shows the effects of a 15‐min preincubation with 3 µM erythromycin on the concentration dependence of I hERG inhibition by terfenadine and thioridazine, with representative traces of effects of single drug concentrations shown in Figure xref i–bi and concentration–response relations shown in Figure xref ii–bii."
reach
"Thioridazine, perphenazine, trifluoperazine, and chlorpromazine blocked hERG potassium channels with the following IC (50) values : IC (50) values were 224 +/- 42 nM for thioridazine, 1003 +/- 71 nM for perphenazine, 1406 +/- 124 nM for trifluoperazine, and 1561 +/- 281 nM for chloropromazine."
sparser
"Figure xref shows the concentration dependence of I hERG inhibition by erythromycin, terfenadine and thioridazine under the recording conditions of this study, with representative traces of effects of single drug concentrations shown in Figure xref i–ci and concentration–response relations shown in Figure xref ii–cii."
sparser
"The IC 50 for I hERG tail inhibition by thioridazine in the presence of erythromycin was 46.4 nM (CI 36.3–59.3 nM; n = 4 to 6 cells per concentration; n H = 0.73 [CI 0.58–0.90]) which does not differ from the calculated IC 50 value for I hERG inhibition in the absence of erythromycin as represented by the respective overlapping concentration–response curves in Figure xref ii ( p > ."