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HSPA binds KCNH2. 22 / 22
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"It has been reported that hERG formed complexes with Hsp70 27."
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"Our coimmunoprecipitation results show that THIO aggravated the ubiquitination of the hERG protein (XREF_FIG), and the interactions between hERG and Hsp70 were decreased (XREF_FIG)."
32064022
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"Both HSP70 and HSP90 directly interact with hERG (the human ether-a-go-go-related gene) whose disorders can lead to long-QT syndrome and sudden cardiac death [XREF_BIBR]."
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"Hsp70 interacts with the nascent hERG in the ER while Hsp90 interacts with the terminal hERG in the cytoplasm to facilitate folding [XREF_BIBR]."
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"Therefore, it would be difficult for Hsp70 to recognize and interact with the hERG protein, thereby elongating the interaction of the early hERG protein with Hsp70 and reducing the interaction of hERG protein with Hsp90."
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"These results indicate that THIO disturbed the folding process of the hERG channel by reducing the interaction between hERG and Hsp70, eventually leading to the degradation of disordered hERG proteins."
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"Hsp70 interacts with the nascent hERG in the ER while Hsp90 interacts with the terminal hERG in the cytoplasm to facilitate folding [ xref ]."
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"Previous study has demonstrated that the heat shock protein (Hsp) 70 increases the levels of both immature and mature forms of hERG. xref However, Rut did not change the expression level of Hsp70, as well as the interaction between hERG and Hsp70 (Figure  xref ), indicating that Rut did not interfere with the transport of hERG channels."
33939251
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"We therefore turned to exploring whether THIO prevents maturation of hERG channels via inhibiting chaperone-hERG interactions; to this end, we performed coimmunoprecipitation experiments to determine the association of hERG protein with Hsp70."
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"This effect may have increased the interaction between the initial hERG and Hsp70."
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"Using biochemical and electrophysiological assays we show that the cytosolic chaperones Hsp70 and Hsp90 interact transiently with wild-type hERG."
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"This effect may have increased the interaction between the initial hERG and Hsp70."
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"As illustrated in Figures XREF_FIG and XREF_FIG, hERG and Hsp70 complexes were decreased in the presence of 3muM THIO."
32064022
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"33 However, Rut did not change the expression level of Hsp70, as well as the interaction between hERG and Hsp70 (Figure S4), indicating that Rut did not interfere with the transport of hERG channels."
33939251
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"The formation of the Hsp70 and hERG complex, on the other hand, was unaffected by hypoxia treatment (lane 5 and 6)."
19654002
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"Our data demonstrated that both Kv4.3 and hERG interacted with Hsp70, suggesting that Hsp70 may form complexes with hERG and Kv4.3."
29259226
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"To determine the mechanism of trafficking inhibition, we performed western blot and immunoprecipitation to test folding of hERG by assessing interaction between hERG and Hsp90 and Hsp70."
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"Ficker et al. showed that the cytosolic chaperones Hsp70 interacted with hERG during maturation 27."
29259226
sparser
"Our coimmunoprecipitation results show that THIO aggravated the ubiquitination of the hERG protein ( xref ), and the interactions between hERG and Hsp70 were decreased ( xref )."
32064022
sparser
"These results indicate that THIO disturbed the folding process of the hERG channel by reducing the interaction between hERG and Hsp70, eventually leading to the degradation of disordered hERG proteins."
32064022
sparser
"Meanwhile, THIO increased the degradation of hERG channels via disrupting hERG-Hsp70 interactions."
32064022
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"The interaction between hERG protein and Hsp90 reduced while the interaction between hERG protein and Hsp70 increased by DHB."
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