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USP18 increases the amount of NS2B. 2 / 2
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"Furthermore, USP18 deficiency significantly attenuated the expression of DENV NS2B protein, DENV RNA and DENV viral particles in BMDCs derived from mice lacking the ifnar1 (Fig. 2A–C) and stat1 genes (Fig. 2D–F)."
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"To further address the mechanisms by which USP18 regulated DENV replication, we generated usp18-knockout (KO) A549 cells with the CRISPR technique, which eliminated USP18 in both the cytosol and mitochondrial fractions Fig. 6A,B. Transfection and induced overexpression of USP18-flag upregulated DENV NS2B expression in usp18-KO cells in a dose-dependent manner (Fig. 6C)."
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