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Statements

USP29 activates Mice. 5 / 5
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"The findings enable us to believe that USP29 inhibition prevents cerebral I/R injury in mice."
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"Accordingly, USP29 overexpression-induced SIRT1 inhibition was prevented in mice treated with either PFT-α or miR-34a antagomir (Figure 6(k))."
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"Systemic knockout of Usp29 depleted MYC and HIF1α in MYC-driven neuroblastoma and B cell lymphoma, inhibited critical metabolic targets and significantly prolonged survival of tumor-bearing mice."
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"And USP29 overexpression also significantly promoted MDA generation in I/R mice (Figure 3(h))."
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"Based on the above results, we conclude that USP29 upregulation during cerebral I/R injury potentiates oxidative stress, apoptosis, and neurological dysfunction in mice."
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