IndraLab

Statements

USP2 activates MDM2. 3 / 4
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"USP2 has been shown to enhance cancer cell proliferative and invasive capabilities by stabilizing and elevating murine double minute 2 (MDM2) protein, which subsequently promotes p53 protein elimination [17, 18]."
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"Although p53 can be activated robustly under both conditions, in contrast to Mdm2 inhibition, USP2 inhibition neither affects Mdm2 induction by p53 nor suppresses Mdm2-mediated repression of p53."
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