IndraLab

Statements

USP37 activates ZBTB16. 3 / 3
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"It was reported that USP37 induced the stability of the oncogenic fusion protein PLZF and RARA."
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"Subsequently, it was verified that USP37 expression modulated the oncogenic fusion protein PLZF/RARA stability and cell transformation potential in PLZF/RARA-associated acute promyelocytic leukemia [33]."
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"Furthermore, overexpression or depletion of USP37 caused an increase or decrease of PLZF and RARA protein half-life, correlating with down- or upregulation of PLZF and RARA poly-ubiquitination, respectively."
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