IndraLab

Statements

UCHL5 deubiquitinates E2F1. 4 / 4
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"Here we identify UCH37 as the first, to our knowledge, deubiquitinating enzyme for E2F1."
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"In addition, Uch37 deubiquitinates E2 promoter binding factor 1 (E2F1), promoting transcription of pro apoptotic and cell cycle related genes XREF_BIBR."
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"Instead, UCH37, but not a catalytically dead mutant, decreases the Lys-63-linked ubiquitination of E2F1 and activates its transcriptional activity."
26396186
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"UCHL5 activates the E2F1 transcriptional activity by decreasing Lys-63-linked ubiquitination of E2F1."
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