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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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UCHL5 deubiquitinates E2F1. 4 / 4

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"Here we identify UCH37 as the first, to our knowledge, deubiquitinating enzyme for E2F1."

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"In addition, Uch37 deubiquitinates E2 promoter binding factor 1 (E2F1), promoting transcription of pro apoptotic and cell cycle related genes XREF_BIBR."

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"Instead, UCH37, but not a catalytically dead mutant, decreases the Lys-63-linked ubiquitination of E2F1 and activates its transcriptional activity."

26396186

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"UCHL5 activates the E2F1 transcriptional activity by decreasing Lys-63-linked ubiquitination of E2F1."

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UCHL5 deubiquitinates E2F1. 4 / 4

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