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"We observed age dependent changes in glutamate uptake, glutamine synthetase (GS) activity, the glutathione (GSH) system, pro inflammatory cytokine (tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta)) release, and the transcriptional activity of nuclear factor kB (NFkB), which were prevented by guanosine in an HO-1-dependent manner."