IndraLab

Statements

CTNNB1 ubiquitinates CTNNB1. 35 / 35
| 32 3
reach
"A complex is formed consisting of and APC, Axin, beta-catenin, beta-TrCP and WTX, which promotes beta-catenin ubiquitination and subsequent proteasomal degradation."
24931005
reach
"Β-catenin activation by GSK3 results in ubiquitination and degradation of β-catenin by proteasome to stop gene expression."
35900667
reach
"Mutations or deletions in CTNNB1 exon 3 prevent the ubiquitination of its protein product, beta-catenin, leading to its nuclear translocation and trans-activation of target genes."
18701503
reach
"Axin-1 is a key protein component of the Wnt signaling pathway [XREF_BIBR] acting as a scaffolding protein, assembling the beta-catenin destruction complex that phosphorylates and subsequently polyubiquitinates beta-catenin [XREF_BIBR - XREF_BIBR]."
28355271
reach
"In the absence of Wnt ligands, CK1 and GSK3beta catalyse beta-catenin N-terminal phosphorylation which triggers beta-catenin ubiquitination and subsequent degradation by the proteasome."
29044515
reach
"(2) In the cytoplasm of shrimp, β-catenin is ubiquitinated by WSSV infection, which also promotes the translocation of β-catenin into nucleus to inhibit the expression of virus immediate early gene wssv069."
34122458
reach
"IKKalpha mediated beta-Catenin phosphorylation inhibits beta-Catenin ubiquitination and degradation, and stimulates beta-Catenin and T-cell factor dependent cyclin D1 expression, which enhances tumor proliferation."
18794072
reach
"PA-mediated beta-catenin palmitoylation inhibits the ubiquitination of beta-catenin."
36878899
reach
"Consistently, we also detected increased ubiquitination of nuclear beta-catenin in ETV4 deficient cells compared to control cells by beta-catenin co-immunoprecipitation in the presence of MG132."
29371979
reach
"These findings suggested that K394 and K281 of CTNNB1 are important for FBXW7-mediated CTNNB1 ubiquitination, and that mutations of these sites can significantly reduce UB modification catalyzed by FBXW7 (Fig. 9C)."
39990660
reach
"Meanwhile, Co-IP assays using anti-β-catenin antibodies reconfirmed that LAPTM4B interacted with β-catenin, USP1, and USP14.Given that LAPTM4B might inhibit β-catenin ubiquitination degradation by assisting USP1 and USP14 in binding to β-catenin (Fig. S6A), we overexpressed various LAPTM4B truncations in CD133 Huh7 cells to further clarify the interaction domain of LAPTM4B with USP1 and USP14."
40171299
reach
"The levels of cytoplasmic beta-catenin are normally controlled by a multi-proteins destruction complex to promote phosphorylation of beta-catenin, which is required to trigger ubiquitination of beta-catenin and its subsequent degradation by proteasomes."
24015932
sparser
"Consistently, Western blot analysis showed strong bands of β-catenin and ubiquitinated β-catenin (mediating the degradation and turnover of β-catenin) for the AGG and the EB groups, but weak expressio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26410789
reach
"Under physiological conditions the majority of cytoplasmic beta-catenin is efficiently bound, phosphorylated and ubiquitylated by the beta-catenin destruction complex 17."
28808228
reach
"The absence of Wnt ligand on the frizzled (FZD) receptor, results in the formation of a complex comprising Disheveled, Axin, APC, GSK-3β, and β-catenin, in which GSK-3β phosphorylates and β-TrCP (an E3 ubiquitin ligase) ubiquitylates β-catenin to promote its proteasome-mediated degradation [24,25]."
35744950
reach
"In quiescent cells, beta-catenin in the cytoplasm is constitutively associated with adenoma polyposis coli (APC), axin, glycogen synthase kinase 3beta (GSK-3beta), and casein kinase I, resulting in the assembly of a beta-catenin destruction complex, which leads to polyubiquitination of beta-catenin and degradation by the proteasome."
| PMC
reach
"Thus, by inhibiting Trankyrase, the β-catenin destruction complex can assemble and lead to the ubiquitination and degradation of β-catenin [46]."
38147228
reach
"This interaction inhibits both the ubiquitination of β-catenin by the β-catenin destruction complex and, subsequently, its degradation [63]."
35985943
reach
"In the absence of Wnt ligands, β-catenin phosphorylation, ubiquitination, and proteasome degradation, mediated by a β-catenin destruction complex, leads to low cytoplasmic β-catenin levels (Liebner and Plate, 2010)."
35799511
reach
"In the absence of a Wnt signal, hyperphosphorylation of CKI prephosphorylated beta-catenin by GSK-3 results in ubiquitination and degradation of beta-catenin."
16275766
reach
"CTNNB1 phosphorylation at serine-33, serine-37, and threonine-41 residues by GSK3β results in ubiquitination and degradation of CTNNB1 [33] ."
35500882
reach
"Typically, individual reaction mixes with either Ubiquitin, Ube1 and Cdc34A or β-catenin, SCF and compound were preincubated and subsequently mixed to initiate β-catenin ubiquitylation."
30926793
reach
"APC is a regulator of the assembly of the β-catenin destruction complex, which promotes β-catenin phosphorylation and ubiquitination and leads to its proteasome degradation [14]."
40061138
reach
"GSK3β is a critical regulator of β-catenin destabilization, which promotes the phosphorylation and ubiquitination of β-catenin, leading to β-catenin proteasomal degradation [44]."
33893396
reach
"In the absence of Wnt signaling, Axin, CK1 and GSK3 complexes bind to and phosphorylate β-catenin, which is recognized by E3 ubiquitin ligase β-Trcp, resulting in ubiquitination of β-catenin and degradation by the proteasome."
39316979
reach
"Mutations in exon 3 of CTNNB1 at or around these positions cause decreased phosphorylation, ubiquitination, and proteolysis of β-catenin, which in turn leads to excessive Wnt signaling and activation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36150916
reach
"Mutations or deletions in CTNNB1 exon 3 prevent the ubiquitination of its protein product, beta-catenin, leading to its nuclear translocation and transactivation of target genes."
18821591
reach
"Deletion of the Jade-1 PHDs or the beta-catenin N terminus abrogated beta-catenin ubiquitination (XREF_FIG, lanes 5 and 10; and XREF_SUPPLEMENTARY, lanes 7 and 12)."
18806787
reach
"In addition, the combination of LINC01278 and beta-catenin promotes the beta-catenin ubiquitination-proteasome degradation."
34273985
sparser
"This interaction inhibits both the ubiquitination of β-catenin by the β-catenin destruction complex and, subsequently, its degradation [ xref ]."
35985943
sparser
"Recruitment of the destruction complex to Wnt receptors blocks β-catenin ubiquitination, and accumulation of cytoplasmic phosphorylated β-catenin, which then translocates to the nucleus and complexes with members of the T cell factor (TCF)/lymphoid enhancer factor family of transcription factors to activate target gene transcription ( xref )."
28807667
reach
"Subsequently, the application of proteasome inhibitors suggested that the combination of LINC01278 and β-catenin can promote β-catenin ubiquitination-proteasome degradation."
34273985
reach
"In HCC, EZH2 associated with a long noncoding RNA called lnc-β-Catm and β-catenin induces β-catenin methylation at K49, which, in turn, suppresses the ubiquitination of β-catenin sustaining a high activity of the WNT/β-catenin pathway."
39776536
reach
"The data revealed that derivative #5 overcame LANA-mediated β-catenin stabilization via the enhancement of β-catenin phosphorylation, which leads to β-catenin polyubiquitination and degradation.The phosphorylation of β-catenin is essential for polyubiquitination mediated by the E3 ubiquitin ligase, SCF ."
35014678
reach
"In quiescent cells, β-catenin in the cytoplasm is constitutively associated with adenoma polyposis coli (APC), axin, glycogen synthase kinase 3β (GSK-3β), and casein kinase I, resulting in the assembl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32827927