IndraLab

Statements

CTNNB1 ubiquitinates CTNNB1. 21 / 21
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"In the absence of Wnt ligands, CK1 and GSK3beta catalyse beta-catenin N-terminal phosphorylation which triggers beta-catenin ubiquitination and subsequent degradation by the proteasome."
29044515
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"Typically, individual reaction mixes with either Ubiquitin, Ube1 and Cdc34A or β-catenin, SCF and compound were preincubated and subsequently mixed to initiate β-catenin ubiquitylation."
30926793
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"Recruitment of the destruction complex to Wnt receptors blocks β-catenin ubiquitination, and accumulation of cytoplasmic phosphorylated β-catenin, which then translocates to the nucleus and complexes with members of the T cell factor (TCF)/lymphoid enhancer factor family of transcription factors to activate target gene transcription ( xref )."
28807667
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"The levels of cytoplasmic beta-catenin are normally controlled by a multi-proteins destruction complex to promote phosphorylation of beta-catenin, which is required to trigger ubiquitination of beta-catenin and its subsequent degradation by proteasomes."
24015932
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"In the absence of a Wnt signal, hyperphosphorylation of CKI prephosphorylated beta-catenin by GSK-3 results in ubiquitination and degradation of beta-catenin."
16275766
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"In quiescent cells, beta-catenin in the cytoplasm is constitutively associated with adenoma polyposis coli (APC), axin, glycogen synthase kinase 3beta (GSK-3beta), and casein kinase I, resulting in the assembly of a beta-catenin destruction complex, which leads to polyubiquitination of beta-catenin and degradation by the proteasome."
| PMC
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"GSK3β is a critical regulator of β-catenin destabilization, which promotes the phosphorylation and ubiquitination of β-catenin, leading to β-catenin proteasomal degradation [44]."
33893396
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"In addition, the combination of LINC01278 and beta-catenin promotes the beta-catenin ubiquitination-proteasome degradation."
34273985
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"IKKalpha mediated beta-Catenin phosphorylation inhibits beta-Catenin ubiquitination and degradation, and stimulates beta-Catenin and T-cell factor dependent cyclin D1 expression, which enhances tumor proliferation."
18794072
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"Mutations or deletions in CTNNB1 exon 3 prevent the ubiquitination of its protein product, beta-catenin, leading to its nuclear translocation and transactivation of target genes."
18821591
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"Mutations or deletions in CTNNB1 exon 3 prevent the ubiquitination of its protein product, beta-catenin, leading to its nuclear translocation and trans-activation of target genes."
18701503
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"Consistently, we also detected increased ubiquitination of nuclear beta-catenin in ETV4 deficient cells compared to control cells by beta-catenin co-immunoprecipitation in the presence of MG132."
29371979
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"A complex is formed consisting of and APC, Axin, beta-catenin, beta-TrCP and WTX, which promotes beta-catenin ubiquitination and subsequent proteasomal degradation."
24931005
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"APCL is a wnt and beta-catenin pathway regulator that promotes beta-catenin ubiquitylation and degradation."
30880222
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"Subsequently, the application of proteasome inhibitors suggested that the combination of LINC01278 and β-catenin can promote β-catenin ubiquitination-proteasome degradation."
34273985
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"Under physiological conditions the majority of cytoplasmic beta-catenin is efficiently bound, phosphorylated and ubiquitylated by the beta-catenin destruction complex 17."
28808228
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"Consistently, Western blot analysis showed strong bands of β-catenin and ubiquitinated β-catenin (mediating the degradation and turnover of β-catenin) for the AGG and the EB groups, but weak expressio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26410789
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"Axin-1 is a key protein component of the Wnt signaling pathway [XREF_BIBR] acting as a scaffolding protein, assembling the beta-catenin destruction complex that phosphorylates and subsequently polyubiquitinates beta-catenin [XREF_BIBR - XREF_BIBR]."
28355271
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"(2) In the cytoplasm of shrimp, β-catenin is ubiquitinated by WSSV infection, which also promotes the translocation of β-catenin into nucleus to inhibit the expression of virus immediate early gene wssv069."
34122458
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"Deletion of the Jade-1 PHDs or the beta-catenin N terminus abrogated beta-catenin ubiquitination (XREF_FIG, lanes 5 and 10; and XREF_SUPPLEMENTARY, lanes 7 and 12)."
18806787
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"Recruitment of the destruction complex to Wnt receptors blocks β-catenin ubiquitination and accumulation of cytoplasmic phosphorylated β-catenin, which then translocates to the nucleus and complexes w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28807667