IndraLab

Statements

Mutated BAP1 activates Carcinogenesis. 3 / 3
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"There has been increased interest in the mechanisms by which BAP1 mutations lead to carcinogenesis."
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"We aim to give a concise review of the carcinogenesis caused by BAP1 mutations, and discuss clinical implications including suggested screening guidelines for patients with germline BAP1 mutations, and potential targeted therapeutic options in patients with mutated BAP1."
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"With respect to cancer biology, BAP1 loss confers metabolic advantages to cancer cells that might partially account for how BAP1 mutations increase the susceptibility of tumorigenesis (62,65)."
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