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NS1 inhibits OTUB1. 9 / 9
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"NS1 proteins from a wide range of influenza A virus strains were shown to trigger the proteasomal degradation of OTUB1, thus antagonizing the RIG-I signaling cascade [42]."
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"NS1 sequesters the RIG-I co-factors 14-3-3ε, OTUB1, and signaling molecule TRAF3 and interferes with the translocation of RIG-I to mitochondrial membrane [164,259] and the formation of MAVS–TRAF3 complex [260,261] (Figure 5), respectively.PB1-F2 is another non-structural protein that IAV employs to antagonize the RIG-I signaling."
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"This phenomenon was antagonized by IAV NS1, which triggered proteasomal degradation of newly synthesized OTUB1."
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"Additionally, the promotion of OTUB1 degradation by IAV NS1 has been reported to be a mechanism by which IAV evades the antiviral response [32]; however, OTUB1 expression levels appear to remain constant throughout the IAV life cycle in our study (S4 Fig)."
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"NS1-dependent degradation of OTUB1 was also validated with the H1N1(pdm) strain ( Figure S5 )."
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"To test whether NS1-mediated degradation of OTUB1 was a universal phenomenon, we expressed NS1 variants from different strains of IAV."
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"WT NS1 from PR8 was able to rapidly degrade OTUB1, whereas a mutant lacking the effector domain had no effect on OTUB1 turnover."
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"Collectively, our data indicate that OTUB1-dependent activation of RIG-I is impeded by the presence of IAV NS1 by facilitating its proteasomal degradation.RLRs are critical cytosolic sensors for patho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous research has shown that during viral infection, OTUB1 translocates from the nucleus to the mitochondrial membrane, where it activates RIG-I-dependent immune signaling; however, IAV NS1 can trigger proteasomal degradation of cellular OTUB1 to dampen this antiviral immune response [32]."
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