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Statements

OTUB2 increases the amount of RUNX2. 2 / 2
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"In contrast, OTUB2 deficiency dramatically suppressed VSMC calcification and decreased the expression of RUNX2 and BMP2, and, conversely, increased the expression of α-SMA (Figure 2L-M)."
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reach
"We also found that OTUB2 knockdown suppressed the ALP activity and the expression of the common markers BMP2 and RUNX2 during osteogenesis of MSCs in response to Shh and Smo agonists, which indicated OTUB2 may have effect on osteogenic differentiation by regulating Hh signaling."
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